On Thursday 7 September, shortly after 12:15pm police were called to reports of a collision between a HGV and a car on the A534, Nantwich Road, Crewe.
Emergency services are at the scene and road closures are in place on the junction with Broughton Lane and Manor Way.
The passenger of the car, a woman, has been taken to Royal Stoke Hospital via air ambulance with serious injuries.
The driver of the car, a man, has been taken to Leighton Hospital via road ambulance.
Motorists are urged to avoid the area and find an alternative route if possible.
Anyone with any information in relation to the incident is asked to contact Cheshire police on 101 quoting incident number 337 of 7 September.